Farrelly came out in defence of 'Movie 43' after multiple press reports asked whether it could be the 'worst film ever'.
The film, which has a star-studded cast including Halle Berry, Kate Winslet, Richard Gere and Hugh Jackman, was also mauled unmercifully by critics.
It currently has a lowly 4% 'fresh' rating on reviews aggregator site Rotten Tomatoes.
Taking to Twitter, Farrelly, who helmed the sketch project along with a number of other directors, said: “To the critics - 'Movie 43' is not the end of the world. It's just a $6 million movie where we tried to do something different. Now back off.
“You always complain that Hollywood never gives you new stuff, and then when you get it, you flip out. Lighten up.”
Reviewers have been less than kind about the film, which also stars Emma Stone, Gerard Butler, Dennis Quaid, Uma Thurman, Richard Gere, Halle Berry, Naomi Watts and Seth MacFarlane.
Chicago Sun-Times critic Richard Roeper called it 'the 'Citizen Kane' of awful', while the New Yorker described it as being 'deadly dull, unfunny, offensive, and stultifyingly clumsy'.
Farrelly could still have the last laugh. The film's relatively small $6 million budget along with all the attention the film is getting could mean that it turns a profit in no time, reinforcing the old Hollywood maxim 'there's no such thing as bad publicity'.