Question for Deepak:
What is karma? Can I escape my fate?
Karma is defined as the sequence of action and consequence that connect all experiences. That means there is an underlying science to all that happens to us but that doesn't mean we are prisoners of fate.
The idea of transcending karma through meditation is that by experiencing your non-local self, you identify with your higher self and thereby become detached from actions you were previously identified with.
So you don't change the karma itself, but you change your relationship or connection to it by realizing your true self. Your karma is associated with you by your identification with the ego mind that authored the action. When, through meditation, you come to know your real self, then you transcend all the karma associated with your false self.
It's kind of like quitting a club or organization. Once you make the switch you no longer are subject to the obligations and restrictions you were when you were a member of the group.